XBI
State Street(R) SPDR(R) S&P(R) Biotech ETF
SPDR SERIES TRUST
ETFIndex fund

Portfolio moves

Net position changes between two of this fund's N-PORT snapshots. These are differences between point-in-time reports — not a trade log — and share counts can be affected by splits and other corporate actions.

Dec 31, 2025 → Mar 31, 2026

Expand a category to see the positions behind it, ranked by weight.

Security Shares Dec 2025 Shares Mar 2026 Δ shares End % Δ value
CAPRICOR THERAPEUTICS INC 0 1,171,894 1,171,894 0.44% $35.63M
SELLAS LIFE SCIENCES GROUP INC 0 4,689,810 4,689,810 0.25% $19.84M
ZENAS BIOPHARMA INC 0 906,255 906,255 0.22% $17.72M
VOR BIOPHARMA INC 0 932,400 932,400 0.21% $16.63M
ALLOGENE THERAPEUTICS INC 0 5,212,606 5,212,606 0.16% $12.72M
HYPERLIQUID STRATEGIES INC 0 2,451,336 2,451,336 0.16% $12.48M
VANDA PHARMACEUTICALS INC 0 1,704,031 1,704,031 0.15% $11.77M
OCUGEN INC 0 5,222,819 5,222,819 0.12% $9.45M
ROCKET PHARMACEUTICALS INC 0 2,606,982 2,606,982 0.12% $9.33M
PERSPECTIVE THERAPEUTICS INC 0 1,713,495 1,713,495 0.09% $7.15M
GALECTO INC 0 93,797 93,797 0.03% $2.43M
Security Shares Dec 2025 Shares Mar 2026 Δ shares End % Δ value
AVIDITY BIOSCIENCES 1,358,205 0 -1,358,205 0.00% -$97.97M
CIDARA THERAPEUTICS INC 441,318 0 -441,318 0.00% -$97.48M
EXACT SCIENCES CORP 957,047 0 -957,047 0.00% -$97.20M
DYNAVAX TECHNOLOGIES CORP 3,047,443 0 -3,047,443 0.00% -$46.87M
RAPT THERAPEUTICS INC 546,579 0 -546,579 0.00% -$18.51M
UPSTREAM BIO INC 641,069 0 -641,069 0.00% -$17.41M
GOSSAMER BIO INC 5,182,950 0 -5,182,950 0.00% -$16.07M
IMMUNEERING CORP 2,166,388 0 -2,166,388 0.00% -$14.25M
KEROS THERAPEUTICS 501,687 0 -501,687 0.00% -$10.21M
REZOLUTE INC 2,309,757 0 -2,309,757 0.00% -$5.45M
Security Shares Dec 2025 Shares Mar 2026 Δ shares End % Δ value
APELLIS PHARMACEUTICALS INC 2,856,301 3,390,454 534,153 1.70% $64.65M
MADRIGAL PHARMACEUTICALS INC 175,411 196,408 20,997 1.28% $664.85K
INSMED INC 510,448 607,845 97,397 1.24% $10.56M
APOGEE THERAPEUTICS INC 805,539 1,134,394 328,855 1.19% $34.68M
SUMMIT THERAPEUTICS INC 4,794,427 4,866,448 72,021 1.15% $8.41M
ARROWHEAD PHARMACEUTICALS INC 1,407,073 1,458,207 51,134 1.14% -$1.99M
COGENT BIOSCIENCES INC 1,850,655 2,348,101 497,446 1.13% $24.64M
ALNYLAM PHARMACEUTICALS INC 239,615 264,406 24,791 1.09% -$7.80M
NUVALENT INC-A 765,391 846,768 81,377 1.08% $9.76M
KYMERA THERAPEUTICS INC 977,053 1,039,280 62,227 1.08% $10.54M
NATERA INC 415,680 430,933 15,253 1.07% -$9.05M
NEUROCRINE BIOSCIENCES INC 622,683 654,044 31,361 1.07% -$2.15M
TRAVERE THERAPEUTICS INC 2,818,736 2,863,192 44,456 1.06% -$22.64M
RHYTHM PHARMACEUTICALS INC 925,008 941,162 16,154 1.02% -$17.16M
ARCUTIS BIOTHERAPEUTICS INC 2,866,419 3,437,805 571,386 1.01% -$2.25M
CRISPR THERAPEUTICS AG 1,682,680 1,696,801 14,121 1.01% -$7.52M
IMMUNITYBIO INC 10,063,186 10,244,025 180,839 0.98% $58.65M
BEAM THERAPEUTICS INC 2,946,215 3,248,626 302,411 0.96% -$4.25M
VERA THERAPEUTICS INC 1,429,875 1,912,054 482,179 0.96% $4.51M
ERASCA INC 2,170,944 4,733,094 2,562,150 0.95% $68.51M
ACADIA PHARMACEUTICALS INC 3,302,738 3,412,655 109,917 0.95% -$12.25M
AGIOS PHARMACEUTICALS INC 1,781,008 1,930,324 149,316 0.81% $16.82M
ULTRAGENYX PHARMA INC 2,616,367 3,107,837 491,470 0.81% $4.93M
DISC MEDICINE INC 598,028 1,012,048 414,020 0.81% $17.22M
IMMUNOME INC 1,878,860 2,934,802 1,055,942 0.80% $23.83M
IMMUNOVANT INC 2,192,830 2,566,528 373,698 0.79% $8.01M
BIOCRYST PHARMACEUTICALS INC 6,338,749 6,655,054 316,305 0.79% $13.91M
VERACYTE INC 1,430,968 1,957,681 526,713 0.79% $2.81M
SPYRE THERAPEUTICS INC 884,938 1,069,556 184,618 0.67% $24.96M
GRAIL INC 1,020,826 1,041,295 20,469 0.67% -$33.56M
VIRIDIAN THERAPEUTICS INC 1,652,815 2,667,007 1,014,192 0.65% $731.05K
RECURSION PHARMACEUTICALS INC 16,052,808 16,732,511 679,703 0.64% -$14.29M
KODIAK SCIENCES INC 986,230 1,344,151 357,921 0.64% $23.66M
INTELLIA THERAPEUTICS INC 3,569,495 3,753,333 183,838 0.60% $16.03M
ARCUS BIOSCIENCES INC 1,539,780 2,163,363 623,583 0.58% $10.04M
ARDELYX INC 6,465,673 7,664,448 1,198,775 0.57% $8.22M
ADMA BIOLOGICS INC 4,850,108 4,916,092 65,984 0.55% -$44.17M
NURIX THERAPEUTICS INC 1,499,744 2,809,877 1,310,133 0.54% $15.10M
ORUKA THERAPEUTICS INC 637,656 761,033 123,377 0.46% $18.00M
OLEMA PHARMACEUTICALS INC 745,798 2,471,879 1,726,081 0.46% $18.21M
PALVELLA THERAPEUTICS INC 260,656 274,232 13,576 0.43% $6.90M
BIOHAVEN LTD 3,468,070 3,844,682 376,612 0.40% -$6.63M
MONTE ROSA THERAPEUTICS INC 1,117,486 1,966,731 849,245 0.40% $14.83M
CORVUS PHARMACEUTICALS INC 1,652,375 2,116,858 464,483 0.39% $18.25M
MANNKIND CORP 7,497,212 10,933,657 3,436,445 0.33% -$15.72M
TYRA BIOSCIENCES INC 256,100 655,457 399,357 0.31% $18.37M
GERON CORP 13,618,323 16,613,693 2,995,370 0.31% $6.78M
VIR BIOTECHNOLOGY INC 2,216,403 2,527,795 311,392 0.28% $9.28M
ANNEXON INC 2,347,026 3,823,368 1,476,342 0.26% $9.40M
INHIBRX BIOSCIENCES INC 142,168 296,581 154,413 0.25% $8.71M
COMPASS THERAPEUTICS INC 2,514,338 3,684,989 1,170,651 0.24% $5.99M
SAVARA INC 1,488,896 3,554,970 2,066,074 0.24% $10.43M
SANA BIOTECHNOLOGY INC 4,542,631 6,650,475 2,107,844 0.24% $664.86K
CULLINAN THERAPE 1,021,903 1,307,461 285,558 0.23% $8.00M
ARS PHARMACEUTICALS INC 1,914,798 2,213,506 298,708 0.22% -$4.53M
SIONNA THERAPEUTICS INC 409,080 416,630 7,550 0.21% -$126.85K
ARRIVENT BIOPHARMA INC 478,439 701,088 222,649 0.20% $6.55M
IRONWOOD PHARMA CL A (PEND) 1,074,360 3,999,224 2,924,864 0.17% $10.42M
PRIME MEDICINE INC 3,110,270 3,979,993 869,723 0.17% $3.06M
ALTIMMUNE INC 3,243,800 4,353,091 1,109,291 0.17% $1.70M
ABSCI CORP 3,393,828 4,448,453 1,054,625 0.17% $1.50M
EMERGENT BIOSOLU 1,474,999 1,572,925 97,926 0.16% -$5.18M
REGENXBIO INC 980,913 1,363,810 382,897 0.14% -$2.70M
LEXEO THERAPEUTICS INC 1,692,758 1,862,707 169,949 0.13% -$6.12M
ARBUTUS BIOPHARMA CORP 1,939,237 2,268,065 328,828 0.13% $878.56K
MIMEDX GROUP INC 1,148,277 2,282,660 1,134,383 0.11% $1.24M
ANAVEX LIFE SCIENCES CORP 2,589,739 2,653,883 64,144 0.10% -$1.07M
INVIVYD INC 4,715,076 5,654,625 939,549 0.09% -$4.30M
Security Shares Dec 2025 Shares Mar 2026 Δ shares End % Δ value
State Street Navigator Securities Lending Portfolio II 762,784,395 600,197,246 -162,587,150 7.47% -$162.59M
ALKERMES PLC 3,385,951 3,050,830 -335,121 1.34% $13.14M
TG THERAPEUTICS INC 3,166,842 3,020,301 -146,541 1.25% $5.93M
SCHOLAR ROCK HOLDING CORP 2,151,056 1,961,965 -189,091 1.20% $1.70M
PROTAGONIST THERAPEUTICS INC 1,060,446 878,071 -182,375 1.15% -$70.67K
UNITED THERAPEUTICS CORP DEL 199,853 155,530 -44,323 1.15% -$5.15M
PRAXIS PRECISION MEDICINES INC 370,413 285,252 -85,161 1.14% -$17.27M
BRIDGEBIO PHARMA INC 1,332,926 1,186,816 -146,110 1.10% -$13.82M
PTC THERAPEUTICS INC 1,307,796 1,290,071 -17,725 1.09% -$11.45M
CYTOKINETICS INC 1,606,699 1,331,453 -275,246 1.09% -$14.33M
EXELIXIS INC 2,359,522 2,029,215 -330,307 1.08% -$16.38M
CG ONCOLOGY INC 1,757,253 1,276,920 -480,333 1.08% $13.46M
TWIST BIOSCIENCE CORP 1,893,174 1,808,036 -85,138 1.07% $25.87M
KRYSTAL BIOTECH INC 404,233 332,277 -71,956 1.07% -$13.83M
VAXCYTE INC 2,228,160 1,472,715 -755,445 1.07% -$17.23M
MIRUM PHARMACEUTICALS INC 1,215,159 923,473 -291,686 1.06% -$10.67M
AMICUS THERAPEUTICS INC 8,213,589 5,895,670 -2,317,919 1.06% -$31.71M
IONIS PHARMACEUTICALS INC 1,232,380 1,132,906 -99,474 1.06% -$12.42M
ARCELLX INC 1,158,034 740,785 -417,249 1.06% $9.55M
REGENERON PHARMACEUTICALS INC 133,448 109,400 -24,048 1.05% -$18.48M
INCYTE CORP 1,018,249 895,013 -123,236 1.05% -$16.33M
CELCUITY INC 951,649 731,925 -219,724 1.04% -$11.38M
REVOLUTION MEDICINES INC 1,244,382 850,768 -393,614 1.03% -$16.38M
HALOZYME THERAPEUTICS INC 1,546,804 1,274,489 -272,315 1.03% -$21.73M
BIOGEN INC 545,762 444,855 -100,907 1.02% -$14.49M
ABBVIE INC 430,356 372,103 -58,253 1.01% -$17.40M
GILEAD SCIENCES INC 798,703 580,264 -218,439 1.01% -$17.16M
BIOMARIN PHARMACEUTICAL INC 1,804,534 1,404,601 -399,933 0.99% -$27.90M
ROIVANT SCIENCES LTD 4,787,868 2,864,237 -1,923,631 0.99% -$24.56M
AMGEN INC 307,313 224,546 -82,767 0.98% -$21.58M
VIKING THERAPEUTICS INC 2,582,129 2,369,189 -212,940 0.96% -$13.75M
MODERNA INC 3,338,095 1,513,720 -1,824,375 0.96% -$21.54M
VERTEX PHARMACEUTICALS INC 217,908 172,078 -45,830 0.96% -$21.95M
SAREPTA THERAPEUTICS INC 3,235,338 3,057,030 -178,308 0.83% -$3.10M
DYNE THERAPEUTICS INC 3,895,365 3,437,524 -457,841 0.78% -$13.87M
CATALYST PHARMACEUTICALS INC 2,568,932 2,268,292 -300,640 0.70% -$3.80M
SYNDAX PHARMACEUTICALS INC 2,683,412 2,343,191 -340,221 0.68% -$1.64M
DENALI THERAPEUTICS INC 3,174,147 2,830,854 -343,293 0.68% $1.95M
IDEAYA BIOSCIENCES 2,105,030 1,628,726 -476,304 0.68% -$18.50M
SOLENO THERAPEUTICS INC 1,592,549 1,496,078 -96,471 0.62% -$23.65M
DIANTHUS THERAPEUTICS INC 958,871 586,673 -372,198 0.61% $9.72M
MINERALYS THERAPEUTICS INC 2,130,912 1,773,248 -357,664 0.60% -$29.29M
TANGO THERAPEUTICS INC 3,754,627 1,972,571 -1,782,056 0.51% $8.00M
CELLDEX THERAPEUTICS INC 1,892,703 1,222,480 -670,223 0.48% -$12.63M
NOVAVAX INC 5,459,421 4,667,715 -791,706 0.47% $1.31M
STOKE THERAPEUTICS INC 1,494,391 1,125,672 -368,719 0.46% -$10.78M
VERICEL CORP 1,252,699 1,116,252 -136,447 0.45% -$9.20M
IOVANCE BIOTHERAPEUTICS INC 11,705,488 8,139,873 -3,565,615 0.36% -$3.39M
ANAPTYSBIO INC 585,056 512,175 -72,881 0.35% $41.71K
RELAY THERAPEUTICS INC 3,210,433 2,831,639 -378,794 0.35% $1.01M
UNIQURE N.V. 2,732,955 1,697,402 -1,035,553 0.35% -$37.65M
ORIC PHARMACEUTICALS INC 2,935,786 2,171,512 -764,274 0.34% $3.50M
CAREDX INC 1,510,042 1,480,419 -29,623 0.32% -$2.75M
TAYSHA GENE THERAPIES INC 5,712,858 5,638,911 -73,947 0.31% -$6.21M
DAY ONE BIOPHARMACEUTICALS INC 2,601,616 1,113,401 -1,488,215 0.30% -$375.74K
PRECIGEN INC 6,200,299 6,004,794 -195,505 0.29% -$2.68M
KALVISTA PHARMACEUTICALS INC 1,086,810 1,077,952 -8,858 0.27% $4.15M
CYTOMX THERAPEUTICS INC 4,533,138 4,511,036 -22,102 0.26% $1.89M
KURA ONCOLOGY INC 3,104,937 2,523,230 -581,707 0.26% -$11.75M
JANUX THERAPEUTICS INC 2,903,728 1,424,540 -1,479,188 0.25% -$20.27M
RIGEL PHARMACEUTICALS INC 714,077 708,776 -5,301 0.24% -$11.42M
XENCOR INC 1,619,613 1,422,163 -197,450 0.21% -$7.64M
REPLIMUNE GROUP INC 2,334,806 2,198,386 -136,420 0.21% -$5.88M
BICARA THERAPEUTICS INC 991,186 701,643 -289,543 0.17% -$2.73M
4D MOLECULAR THERAPEUTICS INC 1,382,120 1,318,068 -64,052 0.15% $1.91M
VERASTEM INC 2,143,034 2,014,499 -128,535 0.13% -$5.87M
MYRIAD GENETICS INC 2,472,629 2,160,321 -312,308 0.12% -$5.49M
PROTHENA CORP PLC 1,367,952 983,448 -384,504 0.12% -$3.50M
AKEBIA THERAPEUTICS INC 8,262,059 6,038,997 -2,223,062 0.10% -$4.91M
Security Shares Dec 2025 Shares Mar 2026 Δ shares End % Δ value
PFIZER INC CVR 1,530,714 1,530,714 0 0.09% $0
NOVO NORDISK CVR 2,033,975 2,033,975 0 0.02% $0
Sanofi Aatd, Inc., CVR 1,645,973 1,645,973 0 0.01% $0
Mirati Therapeutics, Inc., CVR 1,369,552 1,369,552 0 0.01% $0
VERVE THERAPEUTICS INC RTS 900,273 900,273 0 0.01% $0
CONTRA BLUEPRINT MEDIC COMMON STOCK 756,469 756,469 0 0.00% $0
OMNIAB INC - 15.00 EARNOUT 161,959 161,959 0 0.00% $0
OMNIAB INC - 12.5 EARNOUT 161,959 161,959 0 0.00% $0

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