# Portfolio overlap — XBI vs LABU

Comparing **State Street(R) SPDR(R) S&P(R) Biotech ETF** (2026-03-31) and **Direxion Daily S&P Biotech Bull 3X Shares** (2026-04-30).

- Shared positions: 138
- State Street(R) SPDR(R) S&P(R) Biotech ETF covered by Direxion Daily S&P Biotech Bull 3X Shares: 0.7219820891604014524369160662
- Direxion Daily S&P Biotech Bull 3X Shares covered by State Street(R) SPDR(R) S&P(R) Biotech ETF: 0.7219820891604014524369160662

## State Street(R) SPDR(R) S&P(R) Biotech ETF — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| State Street Navigator Securities Lending Portfolio II | 0.074734 |  |
| APELLIS PHARMACEUTICALS INC | 0.016984 | ✓ |
| ALKERMES PLC | 0.013432 |  |
| MADRIGAL PHARMACEUTICALS INC | 0.012802 | ✓ |
| TG THERAPEUTICS INC | 0.012493 | ✓ |
| INSMED INC | 0.012376 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.012010 | ✓ |
| APOGEE THERAPEUTICS INC | 0.011889 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.011524 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.011489 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.011484 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.011444 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.011384 | ✓ |
| COGENT BIOSCIENCES INC | 0.011253 | ✓ |
| BRIDGEBIO PHARMA INC | 0.010974 | ✓ |
| PTC THERAPEUTICS INC | 0.010944 | ✓ |
| CYTOKINETICS INC | 0.010927 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.010893 | ✓ |
| EXELIXIS INC | 0.010837 | ✓ |
| NUVALENT INC-A | 0.010802 | ✓ |
| KYMERA THERAPEUTICS INC | 0.010778 | ✓ |
| CG ONCOLOGY INC | 0.010761 | ✓ |
| NATERA INC | 0.010731 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.010729 | ✓ |
| TWIST BIOSCIENCE CORP | 0.010698 | ✓ |
| KRYSTAL BIOTECH INC | 0.010688 | ✓ |
| VAXCYTE INC | 0.010656 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.010622 | ✓ |
| AMICUS THERAPEUTICS INC | 0.010615 |  |
| IONIS PHARMACEUTICALS INC | 0.010593 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.010592 | ✓ |
| ARCELLX INC | 0.010591 |  |
| REGENERON PHARMACEUTICALS INC | 0.010525 | ✓ |
| INCYTE CORP | 0.010489 | ✓ |
| CELCUITY INC | 0.010402 | ✓ |
| REVOLUTION MEDICINES INC | 0.010302 | ✓ |
| HALOZYME THERAPEUTICS INC | 0.010256 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.010192 | ✓ |
| BIOGEN INC | 0.010155 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.010085 | ✓ |
| ABBVIE INC | 0.010077 | ✓ |
| GILEAD SCIENCES INC | 0.010070 | ✓ |
| CRISPR THERAPEUTICS AG | 0.010050 |  |
| BIOMARIN PHARMACEUTICAL INC | 0.009880 | ✓ |
| ROIVANT SCIENCES LTD | 0.009879 |  |
| AMGEN INC | 0.009838 | ✓ |
| IMMUNITYBIO INC | 0.009783 | ✓ |
| BEAM THERAPEUTICS INC | 0.009639 | ✓ |
| VIKING THERAPEUTICS INC | 0.009599 | ✓ |
| VERA THERAPEUTICS INC | 0.009578 | ✓ |

## Direxion Daily S&P Biotech Bull 3X Shares — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| DREYFUS GOVT CASH MGMT FUND | 0.074333 |  |
| US ULTRA BOND CBT Sep25 | 0.072638 |  |
| GOLDMAN FINL SQ TRSRY INST 506 | 0.062671 |  |
| GOLDMAN SACHS FIN GOV 465 INSTITUT | 0.017087 |  |
| APELLIS PHARMACEUTICALS INC | 0.014425 | ✓ |
| REVOLUTION MEDICINES INC | 0.012740 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.012532 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.011134 | ✓ |
| TWIST BIOSCIENCE CORP | 0.010981 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.010852 | ✓ |
| ALKERMES PLC | 0.010687 |  |
| TG THERAPEUTICS INC | 0.010602 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.010554 | ✓ |
| BEAM THERAPEUTICS INC | 0.010239 | ✓ |
| APOGEE THERAPEUTICS INC | 0.009771 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.009503 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.009450 | ✓ |
| EXELIXIS INC | 0.009375 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.009338 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.009236 | ✓ |
| NATERA INC | 0.009233 | ✓ |
| CELCUITY INC | 0.009229 | ✓ |
| CRISPR Therapeutics A.G. Series A | 0.009229 |  |
| KRYSTAL BIOTECH INC | 0.009054 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.009031 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.008948 | ✓ |
| INCYTE CORP | 0.008861 | ✓ |
| CG ONCOLOGY INC | 0.008856 | ✓ |
| CYTOKINETICS INC | 0.008851 | ✓ |
| NUVALENT INC-A | 0.008823 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.008800 | ✓ |
| BRIDGEBIO PHARMA INC | 0.008769 | ✓ |
| VAXCYTE INC | 0.008759 | ✓ |
| KYMERA THERAPEUTICS INC | 0.008755 | ✓ |
| BIOGEN INC | 0.008747 | ✓ |
| COGENT BIOSCIENCES INC | 0.008733 | ✓ |
| PTC THERAPEUTICS INC | 0.008722 | ✓ |
| INSMED INC | 0.008611 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.008503 | ✓ |
| ROIVANT SCIENCES | 0.008491 |  |
| HALOZYME THERAPEUTICS INC | 0.008430 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.008295 | ✓ |
| SPYRE THERAPEUTICS INC | 0.008272 | ✓ |
| SOLENO THERAPEUTICS INC | 0.008209 | ✓ |
| ABBVIE INC | 0.008171 | ✓ |
| AMGEN INC | 0.008070 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.008035 | ✓ |
| ULTRAGENYX PHARMA INC | 0.007972 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.007961 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.007957 | ✓ |


## Sources

- N-PORT (fund A) — accession `0001410368-26-055543` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/1064642/000141036826055543/0001410368-26-055543-index.htm>
- N-PORT (fund B) — accession `0001193125-26-287439` (as of 2026-04-30)
  <https://www.sec.gov/Archives/edgar/data/1424958/000119312526287439/0001193125-26-287439-index.htm>

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_Data sourced from U.S. SEC EDGAR filings (Forms N-PORT, N-CEN, and prospectus Risk/Return summaries). FundWatcher is not affiliated with the SEC._

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