# Portfolio overlap — RYBOX vs BIPIX

Comparing **Biotechnology Fund** (2026-03-31) and **BIOTECHNOLOGY ULTRASECTOR PROFUND** (2026-04-30).

- Shared positions: 52
- Biotechnology Fund covered by BIOTECHNOLOGY ULTRASECTOR PROFUND: 0.3785550884518192650172581041
- BIOTECHNOLOGY ULTRASECTOR PROFUND covered by Biotechnology Fund: 0.3785550884518192650172581040

## Biotechnology Fund — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| ABBVIE INC | 0.074620 | ✓ |
| AMGEN INC | 0.052819 | ✓ |
| GILEAD SCIENCES INC | 0.050024 | ✓ |
| VERTEX PHARMACEUTICALS INC | 0.040431 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.035928 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.026282 | ✓ |
| INSMED INC | 0.024772 | ✓ |
| BEONE MEDICINES LTD ADR | 0.023063 |  |
| NATERA INC | 0.021135 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.020871 | ✓ |
| BIOGEN INC | 0.020275 | ✓ |
| ROYALTY PHARMA PLC | 0.019976 |  |
| ILLUMINA INC | 0.017546 |  |
| REVOLUTION MEDICINES INC | 0.017056 | ✓ |
| MODERNA INC | 0.016630 | ✓ |
| ASTRAZENECA PLC | 0.016170 |  |
| ARGENX SE SPONSORED ADR | 0.016155 |  |
| INCYTE CORP | 0.015693 | ✓ |
| VIATRIS INC | 0.015148 |  |
| BRIDGEBIO PHARMA INC | 0.014849 | ✓ |
| ALKERMES PLC | 0.014812 |  |
| JAZZ PHARMA PLC | 0.014757 |  |
| NEUROCRINE BIOSCIENCES INC | 0.014298 | ✓ |
| GUARDANT HEALTH INC | 0.014220 |  |
| ROIVANT SCIENCES LTD | 0.014150 |  |
| IONIS PHARMACEUTICALS INC | 0.013952 | ✓ |
| EXELIXIS INC | 0.013012 | ✓ |
| MEDPACE HOLDINGS INC | 0.012700 |  |
| BIOMARIN PHARMACEUTICAL INC | 0.012551 | ✓ |
| APELLIS PHARMACEUTICALS INC | 0.012355 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.012353 | ✓ |
| CYTOKINETICS INC | 0.011864 | ✓ |
| VAXCYTE INC | 0.011454 | ✓ |
| CRISPR THERAPEUTICS AG | 0.011392 |  |
| HALOZYME THERAPEUTICS INC | 0.010967 | ✓ |
| BIONTECH SE ADR | 0.010730 |  |
| AXSOME THERAPEUTICS INC | 0.010318 |  |
| Ascendis Pharma A/S | 0.010209 |  |
| COGENT BIOSCIENCES INC | 0.009993 | ✓ |
| ARCELLX INC | 0.009989 |  |
| TG THERAPEUTICS INC | 0.009735 | ✓ |
| PTC THERAPEUTICS INC | 0.009638 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.009506 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.009109 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.009028 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.008818 | ✓ |
| AMICUS THERAPEUTICS INC | 0.008241 |  |
| RHYTHM PHARMACEUTICALS INC | 0.007900 | ✓ |
| APOGEE THERAPEUTICS INC | 0.007588 | ✓ |
| KYMERA THERAPEUTICS INC | 0.007254 | ✓ |

## BIOTECHNOLOGY ULTRASECTOR PROFUND — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| US ULTRA BOND CBT Sep25 | 0.286585 |  |
| Invesco Government & Agency Portfolio, Institutional Class | 0.019693 |  |
| APELLIS PHARMACEUTICALS INC | 0.012941 | ✓ |
| REVOLUTION MEDICINES INC | 0.011430 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.011242 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.009989 | ✓ |
| TWIST BIOSCIENCE CORP | 0.009851 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.009735 | ✓ |
| ALKERMES PLC | 0.009587 |  |
| TG THERAPEUTICS INC | 0.009511 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.009470 | ✓ |
| BEAM THERAPEUTICS INC | 0.009185 | ✓ |
| APOGEE THERAPEUTICS INC | 0.008766 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.008525 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.008479 | ✓ |
| EXELIXIS INC | 0.008411 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.008377 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.008283 | ✓ |
| NATERA INC | 0.008282 | ✓ |
| CRISPR Therapeutics A.G. Series A | 0.008279 |  |
| CELCUITY INC | 0.008279 | ✓ |
| KRYSTAL BIOTECH INC | 0.008123 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.008102 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.008028 | ✓ |
| INCYTE CORP | 0.007949 | ✓ |
| CG ONCOLOGY INC | 0.007944 |  |
| CYTOKINETICS INC | 0.007940 | ✓ |
| NUVALENT INC-A | 0.007916 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.007895 | ✓ |
| BRIDGEBIO PHARMA INC | 0.007867 | ✓ |
| VAXCYTE INC | 0.007858 | ✓ |
| KYMERA THERAPEUTICS INC | 0.007854 | ✓ |
| BIOGEN INC | 0.007848 | ✓ |
| COGENT BIOSCIENCES INC | 0.007834 | ✓ |
| PTC THERAPEUTICS INC | 0.007825 | ✓ |
| INSMED INC | 0.007724 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.007628 | ✓ |
| ROIVANT SCIENCES | 0.007618 |  |
| HALOZYME THERAPEUTICS INC | 0.007563 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.007442 | ✓ |
| SPYRE THERAPEUTICS INC | 0.007420 |  |
| SOLENO THERAPEUTICS INC | 0.007364 | ✓ |
| ABBVIE INC | 0.007330 | ✓ |
| AMGEN INC | 0.007242 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.007210 | ✓ |
| ULTRAGENYX PHARMA INC | 0.007152 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.007142 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.007138 | ✓ |
| GILEAD SCIENCES INC | 0.007078 | ✓ |
| BIOMARIN PHARMACEUTICAL INC | 0.007059 | ✓ |


## Sources

- N-PORT (fund A) — accession `0000940400-26-023170` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/899148/000094040026023170/0000940400-26-023170-index.htm>
- N-PORT (fund B) — accession `0000910472-26-009384` (as of 2026-04-30)
  <https://www.sec.gov/Archives/edgar/data/1039803/000091047226009384/0000910472-26-009384-index.htm>

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