# Portfolio overlap — JFNIX vs VHCIX

Comparing **Janus Henderson Global Life Sciences Fund** (2026-03-31) and **VANGUARD HEALTH CARE INDEX FUND** (2026-02-28).

- Shared positions: 68
- Janus Henderson Global Life Sciences Fund covered by VANGUARD HEALTH CARE INDEX FUND: 0.5549353931739646642593983598
- VANGUARD HEALTH CARE INDEX FUND covered by Janus Henderson Global Life Sciences Fund: 0.5549353931739646642593983599

## Janus Henderson Global Life Sciences Fund — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| LILLY ELI and CO | 0.088545 | ✓ |
| JOHNSON&JOHNSON | 0.073036 | ✓ |
| AstraZeneca PLC ORD USD0.25 | 0.045993 |  |
| ABBVIE INC | 0.040577 | ✓ |
| UNITEDHEALTH GRP | 0.031357 | ✓ |
| Novartis AG | 0.028605 |  |
| THERMO FISHER SCIENTIFIC INC | 0.025131 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.024527 | ✓ |
| ARGENX SE SPONSORED ADR | 0.024044 |  |
| ABBOTT LABS | 0.023993 | ✓ |
| BRIDGEBIO PHARMA INC | 0.022201 | ✓ |
| Roche Holding AG CHF0.001 | 0.022145 |  |
| SANOFI | 0.020763 |  |
| VERTEX PHARMACEUTICALS INC | 0.020649 | ✓ |
| REVOLUTION MEDICINES INC | 0.020394 | ✓ |
| INTUITIVE SURGICAL INC | 0.020197 | ✓ |
| HCA HEALTHCARE INC | 0.018844 | ✓ |
| BOSTON SCIENTIFIC CORP | 0.018385 | ✓ |
| AMGEN INC | 0.018316 | ✓ |
| Ascendis Pharma A/S | 0.016540 |  |
| STRYKER CORP | 0.016520 | ✓ |
| DANAHER CORP | 0.016392 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.015053 | ✓ |
| CVS HEALTH CORP | 0.014838 | ✓ |
| MERCK & CO | 0.014805 | ✓ |
| PTC THERAPEUTICS INC | 0.013449 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.013340 | ✓ |
| MCKESSON CORP | 0.013313 | ✓ |
| GILEAD SCIENCES INC | 0.012670 | ✓ |
| GLOBUS MEDICAL INC | 0.012432 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.012205 | ✓ |
| TEVA PHARMACEUTICAL IND ADR | 0.011828 |  |
| VAXCYTE INC | 0.010883 | ✓ |
| MEDTRONIC PLC | 0.009744 | ✓ |
| ELEVANCE HEALTH INC | 0.009326 | ✓ |
| DYNE THERAPEUTICS INC | 0.008834 | ✓ |
| CENCORA INC | 0.008424 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.008201 | ✓ |
| LANTHEUS HOLDING | 0.007584 | ✓ |
| MEDLINE INC-A | 0.007415 | ✓ |
| EDWARDS LIFESCIENCES CORP | 0.007186 | ✓ |
| DEXCOM INC | 0.006796 | ✓ |
| SOLENO THERAPEUTICS INC | 0.006374 | ✓ |
| APOGEE THERAPEUTICS INC | 0.006158 | ✓ |
| UCB SA | 0.006069 |  |
| BECTON DICKINSON and CO | 0.005503 | ✓ |
| GLAUKOS CORP | 0.005493 | ✓ |
| STRUCTURE THERAPEUTICS INC ADR | 0.005291 |  |
| IDEAYA BIOSCIENCES | 0.004744 | ✓ |
| PENUMBRA INC | 0.004667 | ✓ |

## VANGUARD HEALTH CARE INDEX FUND — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| LILLY ELI and CO | 0.125577 | ✓ |
| JOHNSON&JOHNSON | 0.087549 | ✓ |
| ABBVIE INC | 0.060834 | ✓ |
| MERCK & CO | 0.045891 | ✓ |
| UNITEDHEALTH GRP | 0.039411 | ✓ |
| AMGEN INC | 0.031008 | ✓ |
| ABBOTT LABS | 0.030047 | ✓ |
| THERMO FISHER SCIENTIFIC INC | 0.029198 | ✓ |
| GILEAD SCIENCES INC | 0.027424 | ✓ |
| INTUITIVE SURGICAL INC | 0.026783 | ✓ |
| PFIZER INC | 0.023326 |  |
| DANAHER CORP | 0.020142 | ✓ |
| STRYKER CORP | 0.019783 | ✓ |
| VERTEX PHARMACEUTICALS INC | 0.018902 | ✓ |
| BRISTOL-MYERS SQUIBB CO | 0.018837 |  |
| MEDTRONIC PLC | 0.018588 | ✓ |
| MCKESSON CORP | 0.018223 | ✓ |
| BOSTON SCIENTIFIC CORP | 0.016897 | ✓ |
| CVS HEALTH CORP | 0.015037 | ✓ |
| HCA HEALTHCARE INC | 0.012874 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.012083 | ✓ |
| THE CIGNA GROUP | 0.011479 |  |
| ELEVANCE HEALTH INC | 0.010514 | ✓ |
| CENCORA INC | 0.010170 | ✓ |
| ZOETIS INC CL A | 0.008621 | ✓ |
| CARDINAL HEALTH INC | 0.008081 |  |
| IDEXX LABS INC | 0.007797 |  |
| EDWARDS LIFESCIENCES CORP | 0.007533 | ✓ |
| BECTON DICKINSON and CO | 0.007506 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.006476 | ✓ |
| GE HEALTHCARE TECHNOLOGIES INC WI | 0.005710 |  |
| RESMED INC | 0.005550 |  |
| AGILENT TECHNOLOGIES INC | 0.005106 |  |
| INSMED INC | 0.004684 |  |
| WATERS CORP | 0.004659 |  |
| IQVIA HOLDINGS INC | 0.004511 |  |
| DEXCOM INC | 0.004273 | ✓ |
| VEEVA SYSTEMS-A | 0.004205 |  |
| METTLER-TOLEDO INTL INC | 0.004178 |  |
| BIOGEN INC | 0.004173 |  |
| NATERA INC | 0.004025 |  |
| STERIS PLC | 0.003688 | ✓ |
| LABCORP HOLDINGS INC | 0.003565 |  |
| QUEST DIAGNOSTICS INC | 0.003517 |  |
| HUMANA INC | 0.003401 | ✓ |
| CENTENE CORP | 0.003271 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.003213 | ✓ |
| TENET HEALTHCARE CORP | 0.003139 |  |
| ILLUMINA INC | 0.003067 | ✓ |
| EXACT SCIENCES CORP | 0.002904 |  |


## Sources

- N-PORT (fund A) — accession `0000277751-26-000145` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/277751/000027775126000145/0000277751-26-000145-index.htm>
- N-PORT (fund B) — accession `0000052848-26-000418` (as of 2026-02-28)
  <https://www.sec.gov/Archives/edgar/data/52848/000005284826000418/0000052848-26-000418-index.htm>

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