# Portfolio overlap — FBT vs RYOIX

Comparing **First Trust NYSE Arca Biotechnology Index Fund** (2026-03-31) and **Biotechnology Fund** (2026-03-31).

- Shared positions: 24
- First Trust NYSE Arca Biotechnology Index Fund covered by Biotechnology Fund: 0.4366080116867893157397499130
- Biotechnology Fund covered by First Trust NYSE Arca Biotechnology Index Fund: 0.4366080116867893157397499130

## First Trust NYSE Arca Biotechnology Index Fund — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| MODERNA INC | 0.052582 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.043554 | ✓ |
| ALKERMES PLC | 0.042325 | ✓ |
| GILEAD SCIENCES INC | 0.040860 | ✓ |
| AXSOME THERAPEUTICS INC | 0.038830 | ✓ |
| AMGEN INC | 0.038301 | ✓ |
| CORCEPT THERAPEUTICS INC | 0.038163 |  |
| KRYSTAL BIOTECH INC | 0.035082 | ✓ |
| BIOGEN INC | 0.034691 | ✓ |
| EXELIXIS INC | 0.034576 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.034444 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.034438 | ✓ |
| VERTEX PHARMACEUTICALS INC | 0.034171 | ✓ |
| BIOMARIN PHARMACEUTICAL INC | 0.034020 | ✓ |
| ARGENX SE SPONSORED ADR | 0.032894 | ✓ |
| SAREPTA THERAPEUTICS INC | 0.032419 | ✓ |
| HALOZYME THERAPEUTICS INC | 0.031662 | ✓ |
| BIONTECH SE ADR | 0.031603 | ✓ |
| INCYTE CORP | 0.031267 | ✓ |
| BEONE MEDICINES LTD ADR | 0.031202 | ✓ |
| ILLUMINA INC | 0.031023 | ✓ |
| NATERA INC | 0.030303 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.029510 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.029494 | ✓ |
| BIO-TECHNE CORP | 0.028241 |  |
| GENMAB A/S -SP ADR DEPOSITARY RECEIPT | 0.027803 |  |
| VERACYTE INC | 0.027201 | ✓ |
| REPLIGEN CORP | 0.025074 |  |
| BRUKER CORP | 0.023547 |  |
| NEOGENOMICS INC | 0.020017 |  |
| DREY-GVT CSH-I | 0.000622 |  |
| DAIWA CAPITAL MARKETS AMERICA INC | 0.000083 |  |

## Biotechnology Fund — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| ABBVIE INC | 0.074620 |  |
| AMGEN INC | 0.052819 | ✓ |
| GILEAD SCIENCES INC | 0.050024 | ✓ |
| VERTEX PHARMACEUTICALS INC | 0.040431 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.035928 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.026282 | ✓ |
| INSMED INC | 0.024772 |  |
| BEONE MEDICINES LTD ADR | 0.023063 | ✓ |
| NATERA INC | 0.021135 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.020871 | ✓ |
| BIOGEN INC | 0.020275 | ✓ |
| ROYALTY PHARMA PLC | 0.019976 |  |
| ILLUMINA INC | 0.017546 | ✓ |
| REVOLUTION MEDICINES INC | 0.017056 |  |
| MODERNA INC | 0.016630 | ✓ |
| ASTRAZENECA PLC | 0.016170 |  |
| ARGENX SE SPONSORED ADR | 0.016155 | ✓ |
| INCYTE CORP | 0.015693 | ✓ |
| VIATRIS INC | 0.015148 |  |
| BRIDGEBIO PHARMA INC | 0.014849 |  |
| ALKERMES PLC | 0.014812 | ✓ |
| JAZZ PHARMA PLC | 0.014757 |  |
| NEUROCRINE BIOSCIENCES INC | 0.014298 | ✓ |
| GUARDANT HEALTH INC | 0.014220 |  |
| ROIVANT SCIENCES LTD | 0.014150 |  |
| IONIS PHARMACEUTICALS INC | 0.013952 |  |
| EXELIXIS INC | 0.013012 | ✓ |
| MEDPACE HOLDINGS INC | 0.012700 |  |
| BIOMARIN PHARMACEUTICAL INC | 0.012551 | ✓ |
| APELLIS PHARMACEUTICALS INC | 0.012355 |  |
| ARROWHEAD PHARMACEUTICALS INC | 0.012353 |  |
| CYTOKINETICS INC | 0.011864 |  |
| VAXCYTE INC | 0.011454 |  |
| CRISPR THERAPEUTICS AG | 0.011392 |  |
| HALOZYME THERAPEUTICS INC | 0.010967 | ✓ |
| BIONTECH SE ADR | 0.010730 | ✓ |
| AXSOME THERAPEUTICS INC | 0.010318 | ✓ |
| Ascendis Pharma A/S | 0.010209 |  |
| COGENT BIOSCIENCES INC | 0.009993 |  |
| ARCELLX INC | 0.009989 |  |
| TG THERAPEUTICS INC | 0.009735 |  |
| PTC THERAPEUTICS INC | 0.009638 |  |
| SCHOLAR ROCK HOLDING CORP | 0.009506 |  |
| MADRIGAL PHARMACEUTICALS INC | 0.009109 |  |
| MIRUM PHARMACEUTICALS INC | 0.009028 |  |
| PROTAGONIST THERAPEUTICS INC | 0.008818 |  |
| AMICUS THERAPEUTICS INC | 0.008241 |  |
| RHYTHM PHARMACEUTICALS INC | 0.007900 |  |
| APOGEE THERAPEUTICS INC | 0.007588 |  |
| KYMERA THERAPEUTICS INC | 0.007254 |  |


## Sources

- N-PORT (fund A) — accession `0000940400-26-021488` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/1329377/000094040026021488/0000940400-26-021488-index.htm>
- N-PORT (fund B) — accession `0000940400-26-023170` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/899148/000094040026023170/0000940400-26-023170-index.htm>

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_Data sourced from U.S. SEC EDGAR filings (Forms N-PORT, N-CEN, and prospectus Risk/Return summaries). FundWatcher is not affiliated with the SEC._

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