# Portfolio overlap — BIPSX vs LABU

Comparing **BIOTECHNOLOGY ULTRASECTOR PROFUND** (2026-04-30) and **Direxion Daily S&P Biotech Bull 3X Shares** (2026-04-30).

- Shared positions: 146
- BIOTECHNOLOGY ULTRASECTOR PROFUND covered by Direxion Daily S&P Biotech Bull 3X Shares: 0.7663599379162377972144992922
- Direxion Daily S&P Biotech Bull 3X Shares covered by BIOTECHNOLOGY ULTRASECTOR PROFUND: 0.7663599379162377972144992922

## BIOTECHNOLOGY ULTRASECTOR PROFUND — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| US ULTRA BOND CBT Sep25 | 0.286585 | ✓ |
| Invesco Government & Agency Portfolio, Institutional Class | 0.019693 |  |
| APELLIS PHARMACEUTICALS INC | 0.012941 | ✓ |
| REVOLUTION MEDICINES INC | 0.011430 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.011242 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.009989 | ✓ |
| TWIST BIOSCIENCE CORP | 0.009851 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.009735 | ✓ |
| ALKERMES PLC | 0.009587 | ✓ |
| TG THERAPEUTICS INC | 0.009511 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.009470 | ✓ |
| BEAM THERAPEUTICS INC | 0.009185 | ✓ |
| APOGEE THERAPEUTICS INC | 0.008766 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.008525 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.008479 | ✓ |
| EXELIXIS INC | 0.008411 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.008377 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.008283 | ✓ |
| NATERA INC | 0.008282 | ✓ |
| CRISPR Therapeutics A.G. Series A | 0.008279 | ✓ |
| CELCUITY INC | 0.008279 | ✓ |
| KRYSTAL BIOTECH INC | 0.008123 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.008102 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.008028 | ✓ |
| INCYTE CORP | 0.007949 | ✓ |
| CG ONCOLOGY INC | 0.007944 | ✓ |
| CYTOKINETICS INC | 0.007940 | ✓ |
| NUVALENT INC-A | 0.007916 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.007895 | ✓ |
| BRIDGEBIO PHARMA INC | 0.007867 | ✓ |
| VAXCYTE INC | 0.007858 | ✓ |
| KYMERA THERAPEUTICS INC | 0.007854 | ✓ |
| BIOGEN INC | 0.007848 | ✓ |
| COGENT BIOSCIENCES INC | 0.007834 | ✓ |
| PTC THERAPEUTICS INC | 0.007825 | ✓ |
| INSMED INC | 0.007724 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.007628 | ✓ |
| ROIVANT SCIENCES | 0.007618 | ✓ |
| HALOZYME THERAPEUTICS INC | 0.007563 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.007442 | ✓ |
| SPYRE THERAPEUTICS INC | 0.007420 | ✓ |
| SOLENO THERAPEUTICS INC | 0.007364 | ✓ |
| ABBVIE INC | 0.007330 | ✓ |
| AMGEN INC | 0.007242 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.007210 | ✓ |
| ULTRAGENYX PHARMA INC | 0.007152 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.007142 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.007138 | ✓ |
| GILEAD SCIENCES INC | 0.007078 | ✓ |
| BIOMARIN PHARMACEUTICAL INC | 0.007059 | ✓ |

## Direxion Daily S&P Biotech Bull 3X Shares — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| DREYFUS GOVT CASH MGMT FUND | 0.074333 |  |
| US ULTRA BOND CBT Sep25 | 0.072638 | ✓ |
| GOLDMAN FINL SQ TRSRY INST 506 | 0.062671 |  |
| GOLDMAN SACHS FIN GOV 465 INSTITUT | 0.017087 |  |
| APELLIS PHARMACEUTICALS INC | 0.014425 | ✓ |
| REVOLUTION MEDICINES INC | 0.012740 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.012532 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.011134 | ✓ |
| TWIST BIOSCIENCE CORP | 0.010981 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.010852 | ✓ |
| ALKERMES PLC | 0.010687 | ✓ |
| TG THERAPEUTICS INC | 0.010602 | ✓ |
| MADRIGAL PHARMACEUTICALS INC | 0.010554 | ✓ |
| BEAM THERAPEUTICS INC | 0.010239 | ✓ |
| APOGEE THERAPEUTICS INC | 0.009771 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.009503 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.009450 | ✓ |
| EXELIXIS INC | 0.009375 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.009338 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.009236 | ✓ |
| NATERA INC | 0.009233 | ✓ |
| CELCUITY INC | 0.009229 | ✓ |
| CRISPR Therapeutics A.G. Series A | 0.009229 | ✓ |
| KRYSTAL BIOTECH INC | 0.009054 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.009031 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.008948 | ✓ |
| INCYTE CORP | 0.008861 | ✓ |
| CG ONCOLOGY INC | 0.008856 | ✓ |
| CYTOKINETICS INC | 0.008851 | ✓ |
| NUVALENT INC-A | 0.008823 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.008800 | ✓ |
| BRIDGEBIO PHARMA INC | 0.008769 | ✓ |
| VAXCYTE INC | 0.008759 | ✓ |
| KYMERA THERAPEUTICS INC | 0.008755 | ✓ |
| BIOGEN INC | 0.008747 | ✓ |
| COGENT BIOSCIENCES INC | 0.008733 | ✓ |
| PTC THERAPEUTICS INC | 0.008722 | ✓ |
| INSMED INC | 0.008611 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.008503 | ✓ |
| ROIVANT SCIENCES | 0.008491 | ✓ |
| HALOZYME THERAPEUTICS INC | 0.008430 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.008295 | ✓ |
| SPYRE THERAPEUTICS INC | 0.008272 | ✓ |
| SOLENO THERAPEUTICS INC | 0.008209 | ✓ |
| ABBVIE INC | 0.008171 | ✓ |
| AMGEN INC | 0.008070 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.008035 | ✓ |
| ULTRAGENYX PHARMA INC | 0.007972 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.007961 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.007957 | ✓ |


## Sources

- N-PORT (fund A) — accession `0000910472-26-009384` (as of 2026-04-30)
  <https://www.sec.gov/Archives/edgar/data/1039803/000091047226009384/0000910472-26-009384-index.htm>
- N-PORT (fund B) — accession `0001193125-26-287439` (as of 2026-04-30)
  <https://www.sec.gov/Archives/edgar/data/1424958/000119312526287439/0001193125-26-287439-index.htm>

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