# Portfolio overlap — BIPIX vs IBB

Comparing **BIOTECHNOLOGY ULTRASECTOR PROFUND** (2026-04-30) and **iShares Biotechnology ETF** (2026-03-31).

- Shared positions: 116
- BIOTECHNOLOGY ULTRASECTOR PROFUND covered by iShares Biotechnology ETF: 0.3133952418781076103047804028
- iShares Biotechnology ETF covered by BIOTECHNOLOGY ULTRASECTOR PROFUND: 0.3133952418781076103047804028

## BIOTECHNOLOGY ULTRASECTOR PROFUND — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| US ULTRA BOND CBT Sep25 | 0.286585 | ✓ |
| Invesco Government & Agency Portfolio, Institutional Class | 0.019693 |  |
| APELLIS PHARMACEUTICALS INC | 0.012941 | ✓ |
| REVOLUTION MEDICINES INC | 0.011430 | ✓ |
| TRAVERE THERAPEUTICS INC | 0.011242 | ✓ |
| ARROWHEAD PHARMACEUTICALS INC | 0.009989 | ✓ |
| TWIST BIOSCIENCE CORP | 0.009851 | ✓ |
| SUMMIT THERAPEUTICS INC | 0.009735 | ✓ |
| ALKERMES PLC | 0.009587 |  |
| TG THERAPEUTICS INC | 0.009511 |  |
| MADRIGAL PHARMACEUTICALS INC | 0.009470 | ✓ |
| BEAM THERAPEUTICS INC | 0.009185 | ✓ |
| APOGEE THERAPEUTICS INC | 0.008766 | ✓ |
| SCHOLAR ROCK HOLDING CORP | 0.008525 | ✓ |
| PRAXIS PRECISION MEDICINES INC | 0.008479 | ✓ |
| EXELIXIS INC | 0.008411 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.008377 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.008283 | ✓ |
| NATERA INC | 0.008282 | ✓ |
| CRISPR Therapeutics A.G. Series A | 0.008279 |  |
| CELCUITY INC | 0.008279 |  |
| KRYSTAL BIOTECH INC | 0.008123 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.008102 | ✓ |
| NEUROCRINE BIOSCIENCES INC | 0.008028 | ✓ |
| INCYTE CORP | 0.007949 | ✓ |
| CG ONCOLOGY INC | 0.007944 | ✓ |
| CYTOKINETICS INC | 0.007940 | ✓ |
| NUVALENT INC-A | 0.007916 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.007895 | ✓ |
| BRIDGEBIO PHARMA INC | 0.007867 | ✓ |
| VAXCYTE INC | 0.007858 | ✓ |
| KYMERA THERAPEUTICS INC | 0.007854 | ✓ |
| BIOGEN INC | 0.007848 | ✓ |
| COGENT BIOSCIENCES INC | 0.007834 | ✓ |
| PTC THERAPEUTICS INC | 0.007825 | ✓ |
| INSMED INC | 0.007724 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.007628 | ✓ |
| ROIVANT SCIENCES | 0.007618 |  |
| HALOZYME THERAPEUTICS INC | 0.007563 | ✓ |
| ARCUTIS BIOTHERAPEUTICS INC | 0.007442 | ✓ |
| SPYRE THERAPEUTICS INC | 0.007420 | ✓ |
| SOLENO THERAPEUTICS INC | 0.007364 |  |
| ABBVIE INC | 0.007330 |  |
| AMGEN INC | 0.007242 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.007210 | ✓ |
| ULTRAGENYX PHARMA INC | 0.007152 | ✓ |
| ACADIA PHARMACEUTICALS INC | 0.007142 | ✓ |
| RHYTHM PHARMACEUTICALS INC | 0.007138 | ✓ |
| GILEAD SCIENCES INC | 0.007078 | ✓ |
| BIOMARIN PHARMACEUTICAL INC | 0.007059 | ✓ |

## iShares Biotechnology ETF — top positions

| Security | Weight | Shared |
|----------|--------|--------|
| BlackRock Cash Funds: Institutional, SL Agency Shares | 0.088091 |  |
| GILEAD SCIENCES INC | 0.070642 | ✓ |
| AMGEN INC | 0.068448 | ✓ |
| VERTEX PHARMACEUTICALS INC | 0.067866 | ✓ |
| REGENERON PHARMACEUTICALS INC | 0.065757 | ✓ |
| ALNYLAM PHARMACEUTICALS INC | 0.036382 | ✓ |
| INSMED INC | 0.029144 | ✓ |
| ARGENX SE SPONSORED ADR | 0.028023 |  |
| BIOGEN INC | 0.022451 | ✓ |
| NATERA INC | 0.022013 | ✓ |
| UNITED THERAPEUTICS CORP DEL | 0.021000 | ✓ |
| BEONE MEDICINES LTD ADR | 0.017638 |  |
| INCYTE CORP | 0.015508 | ✓ |
| MODERNA INC | 0.015352 | ✓ |
| ILLUMINA INC | 0.015320 |  |
| REVOLUTION MEDICINES INC | 0.014015 | ✓ |
| ROIVANT SCIENCES LTD | 0.011325 |  |
| NEUROCRINE BIOSCIENCES INC | 0.010758 | ✓ |
| GENMAB A/S -SP ADR DEPOSITARY RECEIPT | 0.010706 |  |
| BRIDGEBIO PHARMA INC | 0.010325 | ✓ |
| IONIS PHARMACEUTICALS INC | 0.010161 | ✓ |
| MEDPACE HOLDINGS INC | 0.009159 |  |
| MADRIGAL PHARMACEUTICALS INC | 0.009127 | ✓ |
| EXELIXIS INC | 0.009009 | ✓ |
| BIOMARIN PHARMACEUTICAL INC | 0.008955 | ✓ |
| Ascendis Pharma A/S | 0.008728 |  |
| PRAXIS PRECISION MEDICINES INC | 0.007056 | ✓ |
| CHARLES RIVER LABS INTL INC | 0.007012 |  |
| ARROWHEAD PHARMACEUTICALS INC | 0.006863 | ✓ |
| VAXCYTE INC | 0.006821 | ✓ |
| BIO-TECHNE CORP | 0.006757 |  |
| CYTOKINETICS INC | 0.006636 | ✓ |
| HALOZYME THERAPEUTICS INC | 0.006300 | ✓ |
| AXSOME THERAPEUTICS INC | 0.006054 |  |
| BIONTECH SE ADR | 0.005981 |  |
| KRYSTAL BIOTECH INC | 0.005479 | ✓ |
| PROTAGONIST THERAPEUTICS INC | 0.005289 | ✓ |
| REPLIGEN CORP | 0.005249 |  |
| KYMERA THERAPEUTICS INC | 0.004874 | ✓ |
| ALKERMES PLC | 0.004829 |  |
| RHYTHM PHARMACEUTICALS INC | 0.004632 | ✓ |
| Abivax SA SPONSORED ADS | 0.004593 |  |
| PTC THERAPEUTICS INC | 0.004536 | ✓ |
| COGENT BIOSCIENCES INC | 0.004361 | ✓ |
| ARCELLX INC | 0.004328 |  |
| TERNS PHARMACEUTICALS INC | 0.004224 |  |
| NUVALENT INC-A | 0.004088 | ✓ |
| MIRUM PHARMACEUTICALS INC | 0.004072 | ✓ |
| TEMPUS AI INC-A | 0.003928 |  |
| XENON PHARMACEUTICALS INC | 0.003906 |  |


## Sources

- N-PORT (fund A) — accession `0000910472-26-009384` (as of 2026-04-30)
  <https://www.sec.gov/Archives/edgar/data/1039803/000091047226009384/0000910472-26-009384-index.htm>
- N-PORT (fund B) — accession `0002071691-26-012466` (as of 2026-03-31)
  <https://www.sec.gov/Archives/edgar/data/1100663/000207169126012466/0002071691-26-012466-index.htm>

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